NF-kB Links CO2 Sensing to Innate Immunity and Inflammation in Mammalian Cells
نویسندگان
چکیده
منابع مشابه
NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells.
Molecular O(2) and CO(2) are the primary substrate and product of aerobic metabolism, respectively. Levels of these physiologic gases in the cell microenvironment vary dramatically both in health and in diseases, such as chronic inflammation, ischemia, and cancer, in which metabolism is significantly altered. The identification of the hypoxia-inducible factor led to the discovery of an ancient ...
متن کاملRole of NF-kB in the Anti-Inflammatory Effects of Tocotrienols
The NF-kB family of transcription factors regulates genes that are critical for inflammation and immunity. In most cells, NF-kB function is induced upon activation of cells by various stimuli. However, constitutive NF-kB activity is an equally important aspect of NF-kB function that is particularly relevant to chronic inflammation and cancer. Here, we provide a brief overview of NF-kB biology a...
متن کاملMicroenvironment and Immunology A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF-kB in Tumors
Both STAT3 and NF-kB are persistently activated in diverse cancers and promote tumor cell proliferation, survival, angiogenesis, and metastasis through transcriptional activation of multiple common genes. Paradoxically, STAT3 also suppresses many NF-kB–inducible genes involved in innate and adaptive antitumor immunity in spite of elevated levels of NF-kB in tumors. In this study, we show that e...
متن کاملInduction of Heme Oxygenase -1 By Lipocalin 2 Mediated By Nf-Kb Transcription Factor
Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...
متن کاملResidential ventilation and carcinogenesis
The adverse effects of the most widely recognized greenhouse gas and pollutant on the planet, carbon dioxide, are also the most ubiquitously overlooked when present as a (processed) food ingredient, as a (supercritical) solvent and as an excipient. CO2 is a constituent of carbonated beverages, used as an insufflation gas and to elevate alveolar CO2 concentration in acute respiratory distress sy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010